Direct fXa inhibitors (apixaban, rivaroxaban, edoxaban, betrixaban) act by directly inhibiting the serine active site. 1 Given the limited real-world experience in the use of this drug, this overview may serve as useful source for providers to feel more comfortable with its use in practice.įXa inhibitors produce anticoagulant effects by inhibiting the serine active site of fXa, which is responsible for the conversion of prothrombin into activate thrombin during secondary hemostasis. Portola Pharmaceuticals’ andexanet alfa (Andexxa®) has recently garnered significant attention for being the first FDA-approved reversal agent for the factor Xa (fXa) inhibitor class of DOACs. However, like warfarin, DOACs still possess a risk for acute major bleeds. In recent years, direct acting oral anticoagulants (DOACs) have been gaining increased utilization due to fewer drug and food interactions and less frequent blood monitoring required than the traditional anticoagulant of choice, warfarin. Preceptor: Amy Sipe, PharmD, Kansas City VA Medical Center Andexanet Alfa: A Novel Reversal Agent for Factor Xa InhibitorsĪuthor: Christopher Kimes, Pharmacy Student, University of Kansas School of Pharmacy
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